27543
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27543
Fluka
Clindamycin hydrochloride
BioChemika, ≥96.0% (TLC)
| Synonym: | (7S)-7-Chloro-7-deoxylincomycin hydrochloride, Cleocin |
| CAS Number: | 21462-39-5 |
| Linear Formula: | C18H33ClN2O5S · HCl |
| Molecular Weight: | 461.44 |
| Beilstein Registry Number: | 4070786 |
| EC Number: | 244-398-6 |
| MDL number: | MFCD07793327 |
Description
| Biochem/physiol Actions | Spectrum of Activity: Gram positive cocci and taxoplasma. Especially active against anaerobic bacteria. Mode of Action: Inhibits protein synthesis in bacteria by binding the 50s ribosomal subunit. Clindamycin is a semi-synthetic, lincosamide antibiotic that is prepared from lincomycin. It inhibits bacterial protein synthesis by hydrogen bond interactions with the 23S rRNA component of the 50S ribosomal subunit thus inducing dissociation of the peptidyl-t-RNA complex. |
| Other Notes | Antibacterial and antiprotozoal antibiotic of the licosamide class. |
| Review1 |
Properties
| product line | BioChemika |
| assay | ≥96.0% (TLC) |
| solubility | H2O: 50 mg/mL, clear, colorless |
| storage temp. | 2-8°C |
Safety
| Personal Protective Equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
| Safety Statements | 22-24/25 |
| WGK Germany | 2 |
| RTECS | GF2275000 |
Related Products
| Replaced by | C5269, Clindamycin hydrochloride |
References
| Cited Reference | 1. L.W. Brown et al. Anal. Profiles Drug Subst. 10, 75, (1981) |
| reference | Spizek, J., and Rezanka, T., Lincomycin, clindamycin and their applications. Appl. Microbiol. Biotechnol. 64, 455-464, (2004) |
| Tenson, T., et al., The mechanism of action of macrolides, lincosamides and streptogramin B reveals the nascent peptide exit path in the ribosome. J. Mol. Biol. 330, 1005-1014, (2003) | |
| Kouvela, E.C., et al., Unraveling new features of clindamycin interaction with functional ribosomes and dependence of the drug potency on polyamines. J. Biol. Chem. 281, 23103-23110, (2006) | |
| Cullmann,W., et al., Antibacterial activity of oral antibiotics against anaerobic bacteria. Chemotherapy 39, 169-174, (1993) | |
| Leigh, D.A., Antibacterial activity and pharmacokinetics of clindamycin. J. Antimicrob. Chemother. 7 Suppl. A, 3-9, (1981) |
